In Dungeons of Dredmor, the player is sent into a dank, dark dungeon ruled over by Lord Dredmor and patroled by his countless minions, especially “Diggles;” what Fraggles turn into if you feed them after midnight.
Dungeons of Dredmor is much more challenging when using random skills…
…however, my favorite skill-set yet has to be Staves, Viking Wizardry, Promethean Magic, Blood Mage, Ley Walker, Assassination, and Archaeology.
Gain useful experience in farming various dungeon fungi.
Sell items to the greasy merchant by shift clicking the item in your inventory. I made quite a few piles of junk before I figured this one out.
Archaeology: “It Belongs In A Museum” works by casting it on an item with a (funny) name. “This Translation is All Wrong!” also requires a named item. “Ancient Kronian Ritual” unfortunately can only recharge an Anvil of Krong once.
Fleshsmithing: This skill contains the spell “Knit Tissue,” a healing spell, along with a grab-bag of other tricks including a defensive buff and a Zomby pet. Very handy to have around.
Play with Permadeath turned on.